Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

Recombinase-activating gene-2-deficient (Rag2[superscript −/−]) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating events in human colon cancer. Infection of Rag2[superscript −/−] mice with Helicobacter hepaticus led to accumulation of macropha...

Full description

Bibliographic Details
Main Authors: Rao, V. P., Poutahidis, T., Rogers, A. B., Taylor, C. L., Jackson, E. A., Lee, C. W., Schauer, D. B., Erdman, Susan E., Ge, Zhongming, Wogan, Gerald N., Tannenbaum, Steven Robert, Fox, James G.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/96940
https://orcid.org/0000-0003-0771-9889
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/96940
https://orcid.org/0000-0003-0771-9889
https://orcid.org/0000-0001-9307-6116

Similar Items