Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to utilizing B-cells as APCs is their low capacity for non-specific antigen uptake compared to “professional” APCs such as de...

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Bibliographic Details
Main Authors: Lee Szeto, Gregory, Alejandro, Brian, Park, Clara, Frew, Kirubel, Brefo, Mavis S., Mao, Shirley, Heimann, Megan, Van Egeren, Debra S., Sharei, Armon Reza, Worku, Hermoon A., Langer, Robert S, Irvine, Darrell J, Jensen, Klavs F, Szeto, Gregory
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/97090
https://orcid.org/0000-0003-1833-9822
https://orcid.org/0000-0001-7604-1333
https://orcid.org/0000-0001-7192-580X
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/97090
https://orcid.org/0000-0003-1833-9822
https://orcid.org/0000-0001-7604-1333
https://orcid.org/0000-0001-7192-580X
https://orcid.org/0000-0003-4255-0492

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