Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

The influenza polymerase cleaves host RNAs ~10–13 nucleotides downstream of their 5′ ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5′ ends of A/WSN/33 (H1N1) influenza mRNAs. T...

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Bibliographic Details
Main Authors: Koppstein, David Neal Pira, Bartel, David, Ashour, Joseph
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Oxford University Press 2015
Online Access:http://hdl.handle.net/1721.1/97103
https://orcid.org/0000-0002-3872-2856