Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation
The influenza polymerase cleaves host RNAs ~10–13 nucleotides downstream of their 5′ ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5′ ends of A/WSN/33 (H1N1) influenza mRNAs. T...
Main Authors: | Koppstein, David Neal Pira, Bartel, David, Ashour, Joseph |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Oxford University Press
2015
|
Online Access: | http://hdl.handle.net/1721.1/97103 https://orcid.org/0000-0002-3872-2856 |
Similar Items
-
Cap-snatching inhibitors of influenza virus are inhibitory to the in vitro transcription of rice stripe virus
by: Wenzhong Lin, et al.
Published: (2022-09-01) -
Cap snatch prevention: a novel approach to tackle influenza viruses
by: Konstantin M. J. Sparrer, et al.
Published: (2023-05-01) -
High-throughput sequencing of RNA 5'- and 3'-termini yields insights into viral and vertebrate gene expression
by: Koppstein, David N. P. (David Neal Pira)
Published: (2015) -
Structural insights into reptarenavirus cap-snatching machinery.
by: Maria Rosenthal, et al.
Published: (2017-05-01) -
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target
by: Wenjie Wang, et al.
Published: (2020-01-01)