Mechanistic Insight with HBCH[subscript 2]CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases
Polyhydroxybutyrate (PHB) synthases catalyze the polymerization of 3-(R)-hydroxybutyrate coenzyme A (HBCoA) to produce polyoxoesters of 1–2 MDa. A substrate analogue HBCH[subscript 2]CoA, in which the S in HBCoA is replaced with a CH[subscript 2] group, was synthesized in 13 steps using a chemoenzym...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/97199 https://orcid.org/0000-0001-8076-4489 |