Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

How cells in developing organisms interpret the quantitative information contained in morphogen gradients is an open question. Here we address this question using a novel integrative approach that combines quantitative measurements of morphogen-induced gene expression at single-mRNA resolution with...

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Bibliographic Details
Main Authors: Kienle, Simone, Huelsz-Prince, Guizela, Barkoulas, Michalis, van Oudenaarden, Alexander, Van Zon, Jeroen Sebastiaan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/97210