Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant complementary DNAs to identify those that enhanced the survival of cancer cells in the presence of 13 clinically relevant, targeted the...

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Bibliographic Details
Main Authors: Martz, C. A., Ottina, Kathleen, Singleton, K. R., Jasper, J. S., Wardell, S. E., Peraza-Penton, A., Anderson, G. R., Winter, P. S., Alley, H. M., Kwong, L. N., Cooper, Z. A., Tetzlaff, M., Chen, P.-L., Rathmell, J. C., Flaherty, K. T., Wargo, J. A., McDonnell, D. P., Wood, K. C., Wang, Tim, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/97538
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/97538
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

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