A versatile reporter system for CRISPR-mediated chromosomal rearrangements

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Bibliographic Details
Main Authors: Li, Yingxiang, Mou, Haiwei, Colpan, Cansu, Bizhanova, Aizhan, Akama-Garren, Elliot, Joshi, Nik, Feldser, David M., Yin, Hao, Weng, Zhiping, Xue, Wen, Park, Angela I., Hendrickson, Eric A., Anderson, Daniel Griffith, Jacks, Tyler E
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: BioMed Central 2015
Online Access:http://hdl.handle.net/1721.1/97565
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-7045-7837
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793

Internet

http://hdl.handle.net/1721.1/97565
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-7045-7837
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793

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