A versatile reporter system for CRISPR-mediated chromosomal rearrangements
Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2015
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| Online Access: | http://hdl.handle.net/1721.1/97565 https://orcid.org/0000-0001-5785-8911 https://orcid.org/0000-0002-7045-7837 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0001-6898-3793 |