Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all samples. T...
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Format: | Article |
Language: | en_US |
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National Academy of Sciences (U.S.)
2015
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Online Access: | http://hdl.handle.net/1721.1/97586 |