Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease
Huntington’s disease, the most common inherited neurodegenerative disease, is characterized by a dramatic loss of deep-layer cortical and striatal neurons, as well as morbidity in midlife. Human genetic studies led to the identification of the causative gene, huntingtin. Recent genomic advances have...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2015
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| Online Access: | http://hdl.handle.net/1721.1/98028 https://orcid.org/0000-0002-8133-6969 https://orcid.org/0000-0002-6365-8673 |