Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se. Therefore, understand...

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Bibliographic Details
Main Authors: Gagnon, Louis, Sakadzic, Sava, Lesage, Frederic, Musacchia, Joseph J., Lefebvre, Joel, Fang, Qianqian, Yucel, Meryem A., Evans, Karleyton C., Mandeville, Emiri T., Cohen-Adad, Julien, Polimeni, Jonathan R., Yaseen, Mohammad A., Lo, Eng H., Greve, Douglas N., Buxton, Richard B., Dale, Anders M., Devor, Anna, Boas, David A.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Society for Neuroscience 2015
Online Access:http://hdl.handle.net/1721.1/98033

Internet

http://hdl.handle.net/1721.1/98033

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