Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast canc...

Full description

Bibliographic Details
Main Authors: Jeon, Jessie S., Bersini, Simone, Gilardi, Mara, Dubini, Gabriele, Charest, Joseph L., Moretti, Matteo, Kamm, Roger Dale
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/98037
https://orcid.org/0000-0002-7232-304X