Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative bacteria. A strategy for combating MDR is to develop efflux pump inhibitors (EPIs) for use in combination with an antiba...

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Bibliographic Details
Main Authors: Opperman, Timothy J., Kwasny, Steven M., Kim, Hong-Suk, Nguyen, Son T., Houseweart, Chad, D'Souza, Sanjay Victor, Walker, Graham C., Peet, Norton P., Nikaido, Hiroshi, Bowlin, Terry L.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Society for Microbiology 2015
Online Access:http://hdl.handle.net/1721.1/98344
https://orcid.org/0000-0001-7243-8261

Internet

http://hdl.handle.net/1721.1/98344
https://orcid.org/0000-0001-7243-8261

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