A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified ma...

Full description

Bibliographic Details
Main Authors: Meacham, Corbin Elizabeth, Lawton, Lee N., Pritchard, Justin R., Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T., Young, Richard A., Soto Feliciano, Yadira Marie, Hemann, Michael, Joughin, Brian Alan
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2015
Online Access:http://hdl.handle.net/1721.1/98392
https://orcid.org/0000-0001-5118-8478
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0001-7963-402X

Internet

http://hdl.handle.net/1721.1/98392
https://orcid.org/0000-0001-5118-8478
https://orcid.org/0000-0001-8855-8647
https://orcid.org/0000-0001-7963-402X

Similar Items