Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination strategies remain underexplored. To develop a novel the...

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প্রধান লেখক: Faber, Anthony C., Costa, Carlotta, Dastur, Anahita, Gomez-Caraballo, Maria, Robbins, Rebecca, Wagner, Bethany L., Rideout, William M., Jakubik, Charles T., Ham, Jungoh, Edelman, Elena J., Ebi, Hiromichi, Yeo, Alan T., Hata, Aaron N., Song, Youngchul, Patel, Neha U., March, Ryan J., Tam, Ah Ting, Milano, Randy J., Boisvert, Jessica L., Hicks, Mark A., Elmiligy, Sarah, Malstrom, Scott E., Rivera, Miguel N., Harada, Hisashi, Windle, Brad E., Ramaswamy, Sridhar, Benes, Cyril H., Engelman, Jeffrey A., Farago, Anna, Jacks, Tyler E
অন্যান্য লেখক: Koch Institute for Integrative Cancer Research at MIT
বিন্যাস: প্রবন্ধ
ভাষা:en_US
প্রকাশিত: National Academy of Sciences (U.S.) 2015
অনলাইন ব্যবহার করুন:http://hdl.handle.net/1721.1/98407
https://orcid.org/0000-0001-5785-8911

আন্তর্জাল

http://hdl.handle.net/1721.1/98407
https://orcid.org/0000-0001-5785-8911

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