In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex

A wide variety of prokaryotes possess DNA modifications consisting of sequence-specific phosphorothioates (PT) inserted by members of a five-gene cluster. Recent genome mapping studies revealed two unusual features of PT modifications: short consensus sequences and partial modification of a specific...

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Bibliographic Details
Main Authors: Cao, Bo, Zheng, Xiaoqing, Cheng, Qiuxiang, Yao, Fen, Zheng, Tao, Ramesh Babu, I., Zhou, Huchen, You, Delin, Dedon, Peter C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/98432
https://orcid.org/0000-0003-1615-1578
https://orcid.org/0000-0003-0011-3067