Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Dominant mutations in five tRNA synthetases cause Charcot–Marie–Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease. However, previous studies showed that loss of aminoacylation activity is not required to cause CMT. Here we present a Drosophila model for CM...

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Bibliographic Details
Main Authors: Niehues, Sven, Bussmann, Julia, Steffes, Georg, Erdmann, Ines, Sun, Litao, Wagner, Marina, Wang, Guangxia, Koerdt, Sophia N., Stum, Morgane, RajBhandary, Uttam L., Thomas, Ulrich, Aberle, Hermann, Burgess, Robert W., Yang, Xiang-Lei, Dieterich, Daniela, Storkebaum, Erik, Koehrer, Caroline, Schafer, Kerstin, Rajbhandary, Uttam L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/98475
https://orcid.org/0000-0002-4530-5647

Internet

http://hdl.handle.net/1721.1/98475
https://orcid.org/0000-0002-4530-5647

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