Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions

Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions

The availability of therapeutic molecules to targets within cartilage depends on transport through the avascular matrix. We studied equilibrium partitioning and non-equilibrium transport into cartilage of Pf-pep, a 760 Da positively charged peptide inhibitor of the proprotein convertase PACE4. Compe...

Full description

Bibliographic Details
Main Authors: Byun, Sangwon, Tortorella, Micky D., Malfait, Anne-Marie, Fok, Kam, Grodzinsky, Alan J., Frank, Eliot
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/98536
https://orcid.org/0000-0002-4942-3456

Internet

http://hdl.handle.net/1721.1/98536
https://orcid.org/0000-0002-4942-3456

Similar Items