iWRAP: An Interface Threading Approach with Application to Prediction of Cancer-Related Protein–Protein Interactions

Current homology modeling methods for predicting protein–protein interactions (PPIs) have difficulty in the “twilight zone” (< 40%) of sequence identities. Threading methods extend coverage further into the twilight zone by aligning primary sequences for a pair of proteins to a best-fit template...

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Bibliographic Details
Main Authors: Hosur, Raghavendra, Xu, Jinbo, Berger, Bonnie, Bienkowska, Jadwiga R.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/98591
https://orcid.org/0000-0003-2598-3552
https://orcid.org/0000-0002-2724-7228