Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1

Translesion DNA synthesis (TLS) functions as a tolerance mechanism for DNA damage at a potentially mutagenic cost. Three TLS polymerases (Pols) function to bypass DNA damage in Saccharomyces cerevisiae: Rev1, Pol ζ, a heterodimer of the Rev3 and Rev7 proteins, and Pol η (Rad30). Our lab has shown th...

Full description

Bibliographic Details
Main Authors: Wiltrout, Mary Ellen, Walker, Graham C.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99179
https://orcid.org/0000-0002-4647-4282
https://orcid.org/0000-0001-7243-8261