28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures

28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures

The mTOR pathway is a conserved master regulator of translational activity that influences the fate of industrially relevant CHO cell cultures, yet its molecular mechanisms remain unclear. Interestingly, rapamycin specific inhibition of the mTOR pathway in CHO cells was found to down-regulate the sm...

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Bibliographic Details
Main Authors: Courtes, Franck C., Gu, Chen, Wong, Niki S.C., Dedon, Peter C., Yap, Miranda G.S., Lee, Dong-Yup
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99335
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-9920-2080

Internet

http://hdl.handle.net/1721.1/99335
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-9920-2080

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