Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella
Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction–modification (R–M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R–M systems, highly partial PT modification of consensus motifs i...
Main Authors: | , , , , , , , , |
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其他作者: | |
格式: | 文件 |
语言: | en_US |
出版: |
Wiley Blackwell
2015
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在线阅读: | http://hdl.handle.net/1721.1/99340 https://orcid.org/0000-0003-1615-1578 https://orcid.org/0000-0003-0011-3067 https://orcid.org/0000-0001-9920-2080 |