Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella

Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction–modification (R–M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R–M systems, highly partial PT modification of consensus motifs i...

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Main Authors: Cao, Bo, Cheng, Qiuxiang, Gu, Chen, Yao, Fen, DeMott, Michael S., Zheng, Xiaoqing, Deng, Zixin, Dedon, Peter C., You, Delin
其他作者: Massachusetts Institute of Technology. Center for Environmental Health Sciences
格式: 文件
语言:en_US
出版: Wiley Blackwell 2015
在线阅读:http://hdl.handle.net/1721.1/99340
https://orcid.org/0000-0003-1615-1578
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-9920-2080