Quantitative analysis of tRNA modifications by HPLC-coupled mass spectrometry

Post-transcriptional modification of RNA is an important determinant of RNA quality control, translational efficiency, RNA-protein interactions and stress response. This is illustrated by the observation of toxicant-specific changes in the spectrum of tRNA modifications in a stress-response mechanis...

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Bibliographic Details
Main Authors: Su, Dan, Gu, Chen, Lim, Kok Seong, Chionh, Yok Hian, Chan, Clement T. Y., McBee, Megan E., Russell, Brandon S., Ramesh Babu, I., Begley, Thomas J., Dedon, Peter C.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/99341
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0001-8533-2706
https://orcid.org/0000-0001-7940-3459
https://orcid.org/0000-0001-9920-2080