Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

Amine end-modified poly(β-amino ester)s (PBAEs) have generated interest as efficient, biodegradable polymeric carriers for plasmid DNA (pDNA). For cationic, non-degradable polymers, such as polyethylenimine (PEI), the polymer molecular weight (MW) and molecular weight distribution (MWD) significantl...

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Bibliographic Details
Main Authors: Eltoukhy, Ahmed A., Siegwart, Daniel J., Alabi, Christopher A., Rajan, Jay S., Anderson, Daniel Griffith, Langer, Robert S
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99394
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/99394
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492

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