Transport and binding of tumor necrosis factor-α in articular cartilage depend on its quaternary structure

Transport and binding of tumor necrosis factor-α in articular cartilage depend on its quaternary structure

The effect of tumor necrosis factor-α (TNFα) on cartilage matrix degradation is mediated by its transport and binding within the extracellular matrix (ECM) of the tissue, which mediates availability to cell receptors. Since the bioactive form of TNFα is a homotrimer of monomeric subunits, conversion...

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Bibliographic Details
Main Authors: Byun, Sangwon, Sinskey, Yunna L., Lu, Yihong C. S., Frank, Eliot, Grodzinsky, Alan J
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99417
https://orcid.org/0000-0002-4942-3456

Internet

http://hdl.handle.net/1721.1/99417
https://orcid.org/0000-0002-4942-3456

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