Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of immune-modulating compounds into the synapse represents a major challenge. Here,...

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Bibliographic Details
Main Authors: Stephan, Matthias T., Stephan, Sirkka B., Bak, Peter, Chen, Jianzhu, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/99425
https://orcid.org/0000-0002-5687-6154