Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles
Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of immune-modulating compounds into the synapse represents a major challenge. Here,...
Main Authors: | Stephan, Matthias T., Stephan, Sirkka B., Bak, Peter, Chen, Jianzhu, Irvine, Darrell J |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2015
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Online Access: | http://hdl.handle.net/1721.1/99425 https://orcid.org/0000-0002-5687-6154 |
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