Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemi...

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Bibliographic Details
Main Authors: Crespo, Monica P., Abraham, Wuhbet, Chen, Stephanie H., Mueller, Stefanie, Moynihan, Kelly Dare, Melo, Mariane Bandeira, Irvine, Darrell J, Szeto, Gregory, Hanson, Melissa Catherine
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Clinical Investigation 2015
Online Access:http://hdl.handle.net/1721.1/99440
https://orcid.org/0000-0001-7604-1333

Internet

http://hdl.handle.net/1721.1/99440
https://orcid.org/0000-0001-7604-1333

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