Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research
Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99515 https://orcid.org/0000-0003-1787-046X https://orcid.org/0000-0002-7112-1454 |
| _version_ | 1826208041770418176 |
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| author | Nagel, Zachary D. Chaim, Isaac Alexander Samson, Leona D |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Nagel, Zachary D. Chaim, Isaac Alexander Samson, Leona D |
| author_sort | Nagel, Zachary D. |
| collection | MIT |
| description | Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential clinical tools for personalized prevention or treatment of disease. In particular, we highlight research showing that there are significant inter-individual variations in DNA repair capacity (DRC), and that measuring these differences provides important biological insight regarding disease susceptibility and cancer treatment efficacy. We emphasize work showing that it is important to measure repair capacity in multiple pathways, and that functional assays are required to fill a gap left by genome wide association studies, global gene expression and proteomics. Finally, we discuss research that will be needed to overcome barriers that currently limit the use of DNA repair assays in the clinic. |
| first_indexed | 2024-09-23T13:59:35Z |
| format | Article |
| id | mit-1721.1/99515 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:59:35Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/995152022-10-01T18:25:12Z Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research Nagel, Zachary D. Chaim, Isaac Alexander Samson, Leona D Massachusetts Institute of Technology. Center for Environmental Health Sciences Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Nagel, Zachary D. Chaim, Isaac Alexander Samson, Leona D. Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential clinical tools for personalized prevention or treatment of disease. In particular, we highlight research showing that there are significant inter-individual variations in DNA repair capacity (DRC), and that measuring these differences provides important biological insight regarding disease susceptibility and cancer treatment efficacy. We emphasize work showing that it is important to measure repair capacity in multiple pathways, and that functional assays are required to fill a gap left by genome wide association studies, global gene expression and proteomics. Finally, we discuss research that will be needed to overcome barriers that currently limit the use of DNA repair assays in the clinic. 2015-10-29T18:06:16Z 2015-10-29T18:06:16Z 2014-04 Article http://purl.org/eprint/type/JournalArticle 15687864 http://hdl.handle.net/1721.1/99515 Nagel, Zachary D., Isaac A. Chaim, and Leona D. Samson. “Inter-Individual Variation in DNA Repair Capacity: A Need for Multi-Pathway Functional Assays to Promote Translational DNA Repair Research.” DNA Repair 19 (July 2014): 199–213. https://orcid.org/0000-0003-1787-046X https://orcid.org/0000-0002-7112-1454 en_US http://dx.doi.org/10.1016/j.dnarep.2014.03.009 DNA Repair Creative Commons Attribution http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Nagel, Zachary D. Chaim, Isaac Alexander Samson, Leona D Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title | Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title_full | Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title_fullStr | Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title_full_unstemmed | Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title_short | Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research |
| title_sort | inter individual variation in dna repair capacity a need for multi pathway functional assays to promote translational dna repair research |
| url | http://hdl.handle.net/1721.1/99515 https://orcid.org/0000-0003-1787-046X https://orcid.org/0000-0002-7112-1454 |
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