Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic Tissue, and Vaginal Tissue

Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic Tissue, and Vaginal Tissue

HIV seroconversion outcomes in preexposure prophylaxis (PrEP) trials of oral tenofovir (TFV)-containing regimens are highly sensitive to drug concentration, yet less-than-daily dosing regimens are under study. Description of TFV and its active moiety, TFV diphosphate (TFV-DP), in blood, vaginal tiss...

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Bibliographic Details
Main Authors: Louissaint, Nicolette A., Cao, Ying-Jun, Skipper, Paul L., Liberman, Rosa G., Nimmagadda, Sridhar, Anderson, Jean R., Everts, Stephanie, Bakshi, Rahul, Fuchs, Edward J., Hendrix, Craig W., Tannenbaum, Steven Robert
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Mary Ann Liebert, Inc. 2015
Online Access:http://hdl.handle.net/1721.1/99519

Internet

http://hdl.handle.net/1721.1/99519

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