Genomic mining of prokaryotic repressors for orthogonal logic gates
Genetic circuits perform computational operations based on interactions between freely diffusing molecules within a cell. When transcription factors are combined to build a circuit, unintended interactions can disrupt its function. Here, we apply 'part mining' to build a library of 73 TetR...
Main Authors: | Tamsir, Alvin, Clancy, Kevin, Peterson, Todd, Stanton, Brynne C., Nielsen, Alec Andrew, Voigt, Christopher A. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2015
|
Online Access: | http://hdl.handle.net/1721.1/99526 https://orcid.org/0000-0003-0844-4776 https://orcid.org/0000-0003-2171-8460 |
Similar Items
-
Genetic Programs Constructed from Layered Logic Gates in Single Cells
by: Moon, Tae Seok, et al.
Published: (2013) -
Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells
by: Stanton, Brynne C., et al.
Published: (2015) -
Optical and electronic logic gate with orthogonal inputs
by: Xu, Cai
Published: (2018) -
Orthogonally modulated molecular transport junctions for resettable electronic logic gates
by: Meng, Fanben, et al.
Published: (2018) -
Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
by: Peter R Strege, et al.
Published: (2023-03-01)