CRISPR transcriptional repression devices and layered circuits in mammalian cells

CRISPR transcriptional repression devices and layered circuits in mammalian cells

A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device libraries. Here we present a modular transcriptional repression architecture based on clustered regularly interspaced palindromic repeats (CRISPR) system and examine approaches for regulated expression of...

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Bibliographic Details
Main Authors: Kiani, Samira, Beal, Jacob, Huh, Jin, Xie, Zhen, Li, Yinqing, Weiss, Ron, Ebrahimkhani, Mohammad Reza, Hall, Richard N.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/99528
https://orcid.org/0000-0002-6351-7256
https://orcid.org/0000-0003-0396-2443
https://orcid.org/0000-0003-1736-0937

Internet

http://hdl.handle.net/1721.1/99528
https://orcid.org/0000-0002-6351-7256
https://orcid.org/0000-0003-0396-2443
https://orcid.org/0000-0003-1736-0937

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