Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition of this central regulator are little understood. To...

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Bibliographic Details
Main Authors: Tsvetkov, Peter, Zhao, Jinghui, Cikes, Domagoj, Varadarajan, Malini, Santagata, Sandro, Lindquist, Susan, Mendillo, Marc L., Carette, Jan E., Merrill, Parker H., van Diemen, Ferdy R., Penninger, Josef M., Goldberg, Alfred L., Brummelkamp, Thijn R.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: eLife Sciences Publications, Ltd. 2015
Online Access:http://hdl.handle.net/1721.1/99666
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/99666
https://orcid.org/0000-0003-1307-882X

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