Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers

Upon natural infection with pathogens or vaccination, antibodies are produced by a process called affinity maturation. As affinity maturation ensues, average affinity values between an antibody and ligand increase with time. Purified antibodies isolated from serum are invariably heterogeneous with r...

Full description

Bibliographic Details
Main Authors: Eisen, Ellen A., Eisen, Herman N., Kang, Myung Sun, Eisen, Timothy Jonas, Chakraborty, Arup K
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Public Library of Science 2015
Online Access:http://hdl.handle.net/1721.1/99769
https://orcid.org/0000-0002-8800-3438
https://orcid.org/0000-0002-4812-4171
https://orcid.org/0000-0003-1268-9602