Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

Drug-induced liver injury is a major cause of drug development failures and postmarket withdrawals. In vitro models that incorporate primary hepatocytes have been shown to be more predictive than model systems which rely on liver microsomes or hepatocellular carcinoma cell lines. Methods to phenotyp...

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Bibliographic Details
Main Authors: Li, Cheri Yingjie, Stevens, Kelly R., Schwartz, Robert E., Alejandro, Brian S., Huang, Joanne H., Bhatia, Sangeeta N.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Mary Ann Liebert, Inc. 2015
Online Access:http://hdl.handle.net/1721.1/99870
https://orcid.org/0000-0002-1293-2097