A P-loop mutation in Gα subunits prevents transition to the active state : implications for G-protein signaling in fungal pathogenesis

A P-loop mutation in Gα subunits prevents transition to the active state : implications for G-protein signaling in fungal pathogenesis

Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the Gα subunit: exchange of GTP for GDP activates Gα, where...

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Bibliographic Details
Main Authors: Siderovski, David P., Bosch, Dustin E., Willard, Francis S., Kimple, Adam J., Willard, Melinda D., Naqvi, Naweed Issak., Ramanujam, Ravikrishna.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/100154
http://hdl.handle.net/10220/10955

Internet

https://hdl.handle.net/10356/100154
http://hdl.handle.net/10220/10955

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