Frequent cases of RAS-mutated down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Frequent cases of RAS-mutated down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Children with Down syndrome (DS) and acute lymphoblastic leukaemia (ALL) have poorer survival and more relapses than non-DS children with ALL, highlighting an urgent need for deeper mechanistic understanding of DS–ALL. Here, using full-exome or cancer genes-targeted sequencing of 42 ALL samples from...

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Bibliografiske detaljer
Main Authors: Nikolaev, Sergey I., Garieri, Marco, Santoni, Federico, Falconnet, Emilie, Ribaux, Pascale, Guipponi, Michel, Murray, Aoife, Groet, Jürgen, Giarin, Emanuela, Basso, Giuseppe, Nizetic, Dean, Antonarakis, Stylianos E.
Andre forfattere: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Sprog:English
Udgivet: 2014
Fag:
DRNTU::Science::Biological sciences::Human anatomy and physiology
Online adgang:https://hdl.handle.net/10356/101511
http://hdl.handle.net/10220/24153

Internet

https://hdl.handle.net/10356/101511
http://hdl.handle.net/10220/24153

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