Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery

Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery

We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as app...

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Bibliographic Details
Main Authors: Zhang, Xiaoyu, Zhang, Haixia, Xu, Zhigang, Wang, Dongdong, Xu, Shuang, Liu, Xiaoyan
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2014
Subjects:
DRNTU::Engineering::Chemical engineering::Biochemical engineering
Online Access:https://hdl.handle.net/10356/102820
http://hdl.handle.net/10220/19206

Internet

https://hdl.handle.net/10356/102820
http://hdl.handle.net/10220/19206

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