Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery
We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as app...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/102820 http://hdl.handle.net/10220/19206 |
| _version_ | 1826126006832857088 |
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| author | Zhang, Xiaoyu Zhang, Haixia Xu, Zhigang Wang, Dongdong Xu, Shuang Liu, Xiaoyan |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhang, Xiaoyu Zhang, Haixia Xu, Zhigang Wang, Dongdong Xu, Shuang Liu, Xiaoyan |
| author_sort | Zhang, Xiaoyu |
| collection | NTU |
| description | We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as approximately 25 wt % in aqueous solution. In in vitro release studies, these MPEG-SS-PCPT NPs could undergo triggered disassembly and much faster release of CPT under glutathione (GSH) stimulus than in the absence of GSH. The CPT prodrug had high antitumor activity, and another anticancer drug, doxorubicin hydrochloride (DOX⋅HCl), could also be introduced into the prodrug with a high loading amount. The DOX⋅HCl-loaded CPT prodrug could deliver two anticancer drugs at the same time to produce a collaborative cytotoxicity toward cancer cells, which suggested that this GSH-responsive NP system might become a promising carrier to improve drug-delivery efficacy. |
| first_indexed | 2024-10-01T06:45:42Z |
| format | Journal Article |
| id | ntu-10356/102820 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:45:42Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1028202020-03-07T11:40:23Z Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery Zhang, Xiaoyu Zhang, Haixia Xu, Zhigang Wang, Dongdong Xu, Shuang Liu, Xiaoyan School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biochemical engineering We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as approximately 25 wt % in aqueous solution. In in vitro release studies, these MPEG-SS-PCPT NPs could undergo triggered disassembly and much faster release of CPT under glutathione (GSH) stimulus than in the absence of GSH. The CPT prodrug had high antitumor activity, and another anticancer drug, doxorubicin hydrochloride (DOX⋅HCl), could also be introduced into the prodrug with a high loading amount. The DOX⋅HCl-loaded CPT prodrug could deliver two anticancer drugs at the same time to produce a collaborative cytotoxicity toward cancer cells, which suggested that this GSH-responsive NP system might become a promising carrier to improve drug-delivery efficacy. 2014-04-09T09:08:29Z 2019-12-06T21:00:44Z 2014-04-09T09:08:29Z 2019-12-06T21:00:44Z 2014 2014 Journal Article Xu, Z., Wang, D., Xu, S., Liu, X., Zhang, X., & Zhang, H. (2014). Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery. Chemistry - An Asian Journal, 9(1), 199-205. 1861-4728 https://hdl.handle.net/10356/102820 http://hdl.handle.net/10220/19206 10.1002/asia.201301030 en Chemistry - an Asian journal © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biochemical engineering Zhang, Xiaoyu Zhang, Haixia Xu, Zhigang Wang, Dongdong Xu, Shuang Liu, Xiaoyan Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title | Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title_full | Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title_fullStr | Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title_full_unstemmed | Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title_short | Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery |
| title_sort | preparation of a camptothecin prodrug with glutathione responsive disulfide linker for anticancer drug delivery |
| topic | DRNTU::Engineering::Chemical engineering::Biochemical engineering |
| url | https://hdl.handle.net/10356/102820 http://hdl.handle.net/10220/19206 |
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