A U⋅U pair-to-U.C pair mutation-induced RNA native structure destabilisation and stretching-force-induced RNA misfolding

A U⋅U pair-to-U.C pair mutation-induced RNA native structure destabilisation and stretching-force-induced RNA misfolding

Little is known about how a non-Watson–Crick pair affects the RNA folding dynamics. We studied the effects of a U⋅U-to-U⋅C pair mutation on the folding of a hairpin in human telomerase RNA. The ensemble thermal melting of the hairpins shows an on-pathway intermediate with the disruption of the inter...

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Bibliographic Details
Main Authors: Zhong, Zhensheng, Soh, Lai Huat, Lim, Ming Hui, Chen, Gang
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding
Online Access:https://hdl.handle.net/10356/103029
http://hdl.handle.net/10220/25802

Internet

https://hdl.handle.net/10356/103029
http://hdl.handle.net/10220/25802

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