A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.

Bibliographic Details
Main Authors: Wu, Xiaojin, See, Jessica Wei Ting, Xu, Kai, Hirao, Hajime, Roger, Julien, Hierso, Jean-Cyrille, Zhou, Jianrong Steve
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/103739
http://hdl.handle.net/10220/24565