Organocatalytic enantioselective γ-aminoalkylation of unsaturated ester : access to pipecolic acid derivatives
The direct γ-carbon functionalization of α,β-unsaturated esters via N-Heterocyclic Carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optical...
Những tác giả chính: | , , |
---|---|
Tác giả khác: | |
Định dạng: | Journal Article |
Ngôn ngữ: | English |
Được phát hành: |
2014
|
Những chủ đề: | |
Truy cập trực tuyến: | https://hdl.handle.net/10356/104212 http://hdl.handle.net/10220/19439 |