Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector

Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector

Hematopoietic Stem Cell (HSC) targeted gene transfer is an attractive treatment option for a number of hematopoietic disorders caused by single gene defects. However, extensive methylation of promoter sequences results in silencing of therapeutic gene expression. The choice of an appropriate promote...

Full description

Bibliographic Details
Main Authors: Dighe, Niraja, Khoury, Maroun, Mattar, Citra, Chong, Mark, Choolani, Mahesh, Chen, Jianzhu, Antoniou, Michael N., Chan, Jerry Kok Yen
Other Authors: Santiago, Mario L.
Format: Journal Article
Language:English
Published: 2014
Subjects:
DRNTU::Engineering::Chemical engineering::Biochemical engineering
Online Access:https://hdl.handle.net/10356/104904
http://hdl.handle.net/10220/20409

Internet

https://hdl.handle.net/10356/104904
http://hdl.handle.net/10220/20409

Similar Items