Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...
Main Authors: | , , , , , , , , |
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Other Authors: | |
Format: | Journal Article |
Language: | English |
Published: |
2019
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/105824 http://hdl.handle.net/10220/48748 |