Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...

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Bibliographic Details
Main Authors: Siau, Jia Wei, Kannan, Srinivasaraghavan, Ouaray, Zohra, Kwoh, Chee Keong, Ghadessy, Farid, Pradhan, Mohan Rajan, Nguyen, Minh N., Lane, David P., Verma, Chandra Shekhar
Other Authors: School of Computer Science and Engineering
Format: Journal Article
Language:English
Published: 2019
Subjects:
DNA Binding Domain
P53
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/105824
http://hdl.handle.net/10220/48748

Internet

https://hdl.handle.net/10356/105824
http://hdl.handle.net/10220/48748

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