The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best...

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Bibliographic Details
Main Authors: Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter
Other Authors: Leng, Fenfei
Format: Journal Article
Language:English
Published: 2019
Subjects:
HT1080 Cells
DNA Replication
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/105922
http://hdl.handle.net/10220/48858

Internet

https://hdl.handle.net/10356/105922
http://hdl.handle.net/10220/48858

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