Molecular dynamics simulations demonstrate the regulation of DNA-DNA attraction by H4 histone tail acetylations and mutations

The positively charged N-terminal histone tails play a crucial role in chromatin compaction and are important modulators of DNA transcription, recombination, and repair. The detailed mechanism of the interaction of histone tails with DNA remains elusive. To model the unspecific interaction of histon...

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Bibliographic Details
Main Authors: Korolev, Nikolay, Yu, Hang, Lyubartsev, Alexander P., Nordenskiöld, Lars
Other Authors: Case, David A.
Format: Journal Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/106867
http://hdl.handle.net/10220/25198
http://dx.doi.org/10.1002/bip.22499