Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in rea...

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Detalhes bibliográficos
Principais autores: Zhang, Li-Ying, Zhou, Jia-Hui, Xu, Yun-He, Loh, Teck-Peng
Outros Autores: School of Physical and Mathematical Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2015
Assuntos:
Acesso em linha:https://hdl.handle.net/10356/106879
http://hdl.handle.net/10220/25142
http://dx.doi.org/10.1002/asia.201403303