Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in rea...
| Principais autores: | , , , |
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| Outros Autores: | |
| Formato: | Journal Article |
| Idioma: | English |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://hdl.handle.net/10356/106879 http://hdl.handle.net/10220/25142 http://dx.doi.org/10.1002/asia.201403303 |