Mechanism of stapled peptide binding to MDM2 : possible consequences for peptide design
MDM2 is a negative regulator of p53. The N terminal domain of MDM2 interacts with a helical region of the transcriptional activation domain of p53. Stapled peptides have been designed to mimic this interaction, in order to inhibit p53-MDM2 binding and thereby activate the p53 response. Here, we stud...
| Huvudupphovsmän: | , , , |
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| Övriga upphovsmän: | |
| Materialtyp: | Journal Article |
| Språk: | English |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://hdl.handle.net/10356/106916 http://hdl.handle.net/10220/25194 |