A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

Flavivirus RNA replication occurs within a replication complex (RC) that assembles on ER membranes and comprises both non-structural (NS) viral proteins and host cofactors. As the largest protein component within the flavivirus RC, NS5 plays key enzymatic roles through its N-terminal methyltransfera...

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Bibliographic Details
Main Authors: Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y. F., Swaminathan, Kunchithapadam, Cornvik, Tobias Carl, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
Other Authors: Rey, Félix A.
Format: Journal Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Biological sciences::Microbiology::Bacteria
Online Access:https://hdl.handle.net/10356/107252
http://hdl.handle.net/10220/25565

Internet

https://hdl.handle.net/10356/107252
http://hdl.handle.net/10220/25565

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